Clinical Trials

Coordination of and participation in clinical stroke trials is a key mission of our group. Activities in this area focus on the rapid transfer of innovative imaging methods and treatment approaches into clinical trials and routine clinical practice. This involves observational studies as well as coordination of multicenter randomized trials. In running clinical trials we cooperate with national and international networks of stroke researchers.

We have planned and coordinated the FP7-funded investigator-initiated European multicenter randomized controlled trial of MRI-based thrombolysis in stroke patients with unknown time of symptom onset (WAKE-UP) (Thomalla et al., 2018). Together with partners in Heidelberg, we are coordinating the investigator-initiated randomized TENSION trial of thrombectomy in stroke patients with extended stroke lesions and patients presenting in a late time window, who are currently excluded from available effective treatment approaches (Bendszus et al., 2019), which is funded by the European Union’s Horizon 2020 research and innovation programme ( Together with other partners from Germany, we have initiated a large multicenter prospective registry of thrombectomy in clinical practice, the German Stroke registry – Endovascular Treatment (GSR-ET) (Alegiani et al., 2019) (

  • Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, et al. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. N Engl J Med 2018; 379: 611–622.

  • Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp, Anne Hege Aamodt, Blanca Fuentes, Elke R Gizewski, Michael D Hill, Antonin Krajina, Laurent Pierot, Claus Z Simonsen, Kamil Zeleňák, Rolf A Blauenfeldt, Bastian Cheng, Angélique Denis, Hannes Deutschmann, Franziska Dorn, Fabian Flottmann, Susanne Gellißen, Johannes C Gerber, Mayank Goyal, Jozef Haring, Christian Herweh, Silke Hopf-Jensen, Vi Tuan Hua, Märit Jensen, Andreas Kastrup, Christiane Fee Keil, Andrej Klepanec, Egon Kurča, Ronni Mikkelsen, Markus Möhlenbruch, Stefan Müller-Hülsbeck, Nico Münnich, Paolo Pagano, Panagiotis Papanagiotou, Gabor C Petzold, Mirko Pham, Volker Puetz, Jan Raupach, Gernot Reimann, Peter Arthur Ringleb, Maximilian Schell, Eckhard Schlemm, Silvia Schönenberger, Bjørn Tennøe, Christian Ulfert, Kateřina Vališ, Eva Vítková, Dominik F Vollherbst, Wolfgang Wick, Götz Thomalla, on behalf of the TENSION Investigators

    Lancet. 2023;402:1753–1763.

  • Alegiani AC, Dorn F, Herzberg M, Wollenweber FA, Kellert L, Siebert E, et al. Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment. Int J Stroke 2019; 14: 372–380.