FAQs Archiv

Q: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data.

Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O, Bendszus M, Bladin CF, Campbell B, Cheng B, Churilov L, Ebinger M, Endres M, Fiebach JB, Fukuda-Doi M, Inoue M, Kleinig TJ, Latour LL, Lemmens R, Levi C, Leys D, Miwa K, Molina CA, Muir KW, Nighoghossian N, Parsons MW, Pedraza S, Schellinger PD, Schwab S, Simonsen CZ, Song SS, Thijs V, Toni C, Hsu CY, Wahlgren N, Yamamoto H, Yassi N, Yoshimura S, Warach S, Hacke W, Toyoda K, Donnan GA, Davis SM, Gerloff C, on behalf of the Evaluation of unknown Onset Stroke thrombolysis trials (EOS) investigators Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet 2020; 396: 1574–1584.

Q: Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke.

Schlemm E, Ingwersen T, Königsberg A, Boutitie F, Ebinger M, Endres M, Fiebach J, Fiehler J, Galinovic I, Lemmens R, Muir Keith, Nighoghossian N, Pedraza S, Puig J, Simonsen C, Thijs V, Wouters A, Gerloff C, Thomalla, Cheng B Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke. 2021 Nat. Commun. 2021;12:2590.

Q: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset.

Thomalla, G., Simonsen, C. Z., Boutitie, F., Andersen, G., Berthezene, Y., Cheng, B., Cheripelli, B., Cho, T.-H., Fazekas, F., Fiehler, J., Ford, I., Galinovic, I., Gellissen, S., Golsari, A., Gregori, J., Günther, M., Guibernau, J., Häusler, K. G., Hennerici, M., Kemmling, A., Marstrand, J., Modrau, B., Neeb, L., Perez de la Ossa, N., Puig, J., Ringleb, P., Roy, P., Scheel, E., Schonewille, W., Serena, J., Sunaert, S., Villringer, K., Wouters, A., Thijs, V., Ebinger, M., Endres, M., Fiebach, J. B., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S. & Gerloff, C. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. New Engl. J. Med. 379, 611–622 (2018)

Q: DWI-FLAIR mismatch for the identifi cation of patients with acute ischaemic stroke within 4.5 h of symptom onset ( PRE-FLAIR ): a multicentre observational study.

Thomalla, G., Cheng, B., Ebinger, M., Hao, Q., Tourdias, T., Wu, O., Kim, J. S., Breuer, L., Singer, O. C. & Warach, S. DWI-FLAIR mismatch for the identifi cation of patients with acute ischaemic stroke within 4.5 h of symptom onset ( PRE-FLAIR ): a multicentre observational study. Lancet Neurol. 4422, 1–9 (2011).

Q: Influence of Stroke Infarct Location on Functional Outcome Measured by the Modified Rankin Scale

Cheng, B., Forkert, N. D., Zavaglia, M., Hilgetag, C. C., Golsari, A., Siemonsen, S., Fiehler, J., Pedraza, S., Puig, J., Cho, T., Alawneh, J., Baron, J., Ostergaard, L., Gerloff, C. & Thomalla, G. Influence of Stroke Infarct Location on Functional Outcome Measured by the Modified Rankin Scale. Stroke 45, 1695–1702 (2014).

Q: Cortical atrophy and transcallosal diaschisis following isolated subcortical stroke

Cheng, B., Dietzmann, P., Schulz, R., Boenstrup, M., Krawinkel, L., Fiehler, J., Gerloff, C. & Thomalla, G. Cortical atrophy and transcallosal diaschisis following isolated subcortical stroke. J. Cereb. Blood Flow Metab. 40, 611–621 (2020).

Q: Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment

Alegiani, A. C., Dorn, F., Herzberg, M., Wollenweber, F. A., Kellert, L., Siebert, E., Nolte, C. H., von Rennenberg, R., Hattingen, E., Petzold, G. C., Bode, F. J., Pfeilschifter, W., Schäfer, J. H., Wagner, M., Röther, J., Eckert, B., Kraft, P., Pham, M., Boeckh-Behrens, T., Wunderlich, S., Bernkopf, K., Reich, A., Wiesmann, M., Mpotsaris, A., Psychogios, M., Liman, J., Maier, I., Berrouschot, J., Bormann, A., Limmroth, V., Spreer, J., Petersen, M., Krause, L., Lowens, S., Kraemer, C., Zweynert, S., Lange, K. S., Thonke, S., Kastrup, A., Papanagiotou, P., Alber, B., Braun, M., Fiehler, J., Gerloff, C., Dichgans, M. & Thomalla, G. Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment . Int. J. Stroke 14, 372–380 (2019).

Q: Functional Outcome of Intravenous Thrombolysis in Patients with Lacunar Infarcts in the WAKE-UP Trial

Barow, E., Boutitie, F., Cheng, B., Cho, T. H., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Ford, I., Galinovic, I., Nickel, A., Puig, J., Roy, P., Wouters, A., Magnus, T., Thijs, V., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Gerloff, C. & Thomalla, G. Functional Outcome of Intravenous Thrombolysis in Patients with Lacunar Infarcts in the WAKE-UP Trial . JAMA Neurol. 76, 641–649 (2019).

Q: Real-world experience of treatment decision-making in carotid stenosis in a neurovascular board

Rimmele, D. L., Larena-Avellaneda, A., Alegiani, A. C., Rosenkranz, M., Schmidt, N. O., Regelsberger, J., Hummel, F. C., Magnus, T., Debus, E. S., Fiehler, J., Gerloff, C. & Thomalla, G. Real-world experience of treatment decision-making in carotid stenosis in a neurovascular board. Neurology 89, 399–407 (2017).

Q: Structural brain networks and functional motor outcome after stroke—a prospective cohort study

Schlemm, E., Schulz, R., Bönstrup, M., Krawinkel, L., Fiehler, J., Gerloff, C., Thomalla, G. & Cheng, B. Structural brain networks and functional motor outcome after stroke—a prospective cohort study . Brain Commun. 2, (2020).